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| Id: | 21560
| | Autor: | Fernández, José M. M. | | Título: | The early reaction induced by lepromin.
| | Fonte: | Int. J. Lepr;8(1):1-14, Jan.-Mar. 1940. ilus, tab.
| | Resumo: | The intradermal reaction to lepromin has been studied in a total of 563 persons, cases of leprosy and contacts. Observation of its clinical and histopathologic development has shown the following facts: (a) In allergic cases intradermal injection of lepromin induces an "early" reaction which is well defined, both clinically and histologically, beginning a few hours after injection and reaching its maximum between 48 and 72 hours, thereafter decreasing until it disappears completely during the first week. (b) This early reaction, which is manifested clinically by an erythematous halo, usually infiltrated, is not of nospecific character since it only seen in those cases which ofter resistance to the infection (i.e., neural forms of the disease, particularly the tuberculoid form) and does not occur in cases which are considered anergic, as in the lepromatous type. (c) In 95 percent of cases the early reaction coincides with the late nodular reaction in the 3rd week (the classical Mitsuda reaction). (d) The early and late reactions are probably brought about by different substances or toxins of the Hansen bacillus, since a filtrate of lepromin always gives the early reaction in allergic cases whereas only exceptionally does it cause a faint late reaction. (e) When the filterable toxins of the Koch bacillus (tuberculin) and the total toxins of the same (suspension of the bacillus killed by heat) are injected intradermally into lepers, the former only induces an early reaction whereas the latter induces both this reaction and a late one, consisting of a nodule or papule, in the third week. (f) THe previous experiment gives rise to the supposition that, like the Koch bacillus, that of Hansen contains soluble toxins which can be separated from the bacillary organism and insoluble toxins which cannot be thus disassociated, both being capable of producing allergic reactions in sensitized individuals. (g) The early reaction induced by lepromin resembles, clinically and histologically, the Mantoux reaction. Nevertheless, in a comparative study of both reactions in a group of lepers and contacts, the results did not agree in 45 percent of cases. (AU).
| | Descritores: | ANTIGENO DE MITSUDA/admin
ANTIGENO DE MITSUDA/clas
ANTIGENO DE MITSUDA/imunol
HANSENIASE/clas
HANSENIASE/patol
| | Localização: | BR191.1 |
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